Figure 1. The Morris Water Maze was performed 48 hours after the final isoflurane exposure.

The isoflurane exposure, but not the presence of the transgene, significantly affected the escape latency, swimming pathway and the swimming time in the target quadrant during probe test. The average swimming speeds were similar among groups. A: The mean latency to find the platform was shorter following the isoflurane exposure for both the transgenic and wild-type mice. *: p<0.05 on the third day compared with transgenic and wild-type mice not exposed to isoflurane. B: The mean pathway to find the platform was shorter following the isoflurane exposure for both the transgenic and wild-type mice. *: p<0.05 on the third day compared with transgenic and wild-type mice not exposed to isoflurane. C: The swimming speed was similar among the four groups. D: During the probe trial, wild-type mice exposed to isoflurane spent more time in the target quadrant following the isoflurane exposure. The X-axis (days) corresponds to the testing paradigm in Figure 1 (days 8–11). (Ad-iso, n = 20; Ad-con, n = 20; Wt-iso, n = 16; Wt-con, n = 13).