Figure 7. The combination of pan Bcl-2 inhibitor AT-101 with aATC immunotherapy induces Stat1 phosphorylation.

L3.6pl cells were either pretreated with AT-101 for 24 h or left untreated followed by additional incubation with ATC or aATC for 4 h and staining for intracellular phospho-Stat1. Proportion of Stat1 positive cells and MFI were gated on tumor cells. Top panel show histogram overlays representing isotype control and phospho-Stat1 positive tumor cells. Bottom panel shows the graphic representation of MFI under the indicated experimental conditions.