Skip to main content
. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Mol Cancer Res. 2012 Sep 10;10(11):1462–1472. doi: 10.1158/1541-7786.MCR-12-0335

Figure 1. SUZ12 is expressed at significantly higher levels in human EOCs compared with normal human ovarian surface epithelium or fallopian tube epithelium, and predicts poor overall survival in EOC patients.

Figure 1

A, examples of SUZ12 IHC staining in normal human ovarian surface epithelium, fallopian tube epithelium and human EOC (shown is an example of high-grade serous histosubtype EOC specimen). Bar = 100 μm. B, representative images from consecutive, serial sections of the same EOC specimen depicting the positive correlation between expression of SUZ12 and expression of EZH2 and Ki67, a cell proliferation marker. Bar = 100 μm. C, A higher SUZ12 expression correlates with a shorter overall survival in EOC patients. The univariate overall survival curve (Kaplan-Meier method) for EOC patients with high (n = 22) or low (n = 28) SUZ12 expression based on median levels of mRNA expression determined by qRT-PCR in a cohort of 50 EOC patients (p = 0.0078). The p value was calculated based on Log-rank (Mantel-Cox) test using GraphPad Prism version 5.0 software.