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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Clin Immunol. 2012 Oct 7;145(3):209–223. doi: 10.1016/j.clim.2012.09.012

Figure 4.

Figure 4

Defect in suppression of T cell proliferation in MG is primarily intrinsic to isolated Tregs. Experiments in which T cell subsets from MG patients and healthy controls were “cross-cultured” as described in “Materials and methods” are shown. Treg cells from MG patients fail to suppress anti-CD3 induced proliferation in Tresp cells from healthy controls (A and C), while Tregs from healthy controls effectively suppress Tresp from MG patients (B and D). Tregs from healthy controls suppress AChR-α peptide induced proliferation of Tresp from MG patients, whereas autologous MG Tregs mediate only minimal suppression (E,F,G and H).