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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Clin Immunol. 2012 Oct 7;145(3):209–223. doi: 10.1016/j.clim.2012.09.012

Figure 7.

Figure 7

Clinical Correlations of FOXP3 expression and suppressive function of Tregs. FOXP3 expression (MFI) in CD4+CD25highCD127low/− Tregs (A), and percentage suppression of Tresp proliferation by Tregs (B) was determined in 5 patients who were immunosuppression naïve (MG-IS naive) and 18 patients who were treated with immunosuppression (MG + IS). Immunosuppressive treatment was associated with increased FOXP3 expression and Treg suppression of Tresp cell proliferation. (C) An inverse correlation was found between manual muscle testing (MMT) scores and the percentage of Tresp suppression (n=20) with a Spearman’s correlation coefficient of r = −0.443 (p < 0.05).