. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: DNA Repair (Amst). 2012 Oct 17;11(12):942–950. doi: 10.1016/j.dnarep.2012.09.003

Table 1.

Assembly of NER factors in NER deficient XP-B and XP-B/CS fibroblasts

Factor/Cells/Time	GM13025/XPCS1BA	GM13026/XPCS2BA	GM21071/XP33BR	GM21072/XP183MA	GM21153/XP181MA
Factor/Cells/Time	0 0.5 1 3 24h	0 0.5 1 3 24h	0 0.5 1 3 24h	0 0.5 1 3 24h	0 0.5 1 3 24h
XPC	3+ 3+ 3+ 3+ 2+	3+ 3+ 3+ 3+ 2+	3+ 3+ 3+ 3+ 2+	3+ 3+ 3+ 3+ 2+	3+ 3+ 3+ 3+ 2+
XPB	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	- - - - -	- - - - -
XPD	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+
p62	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+	2+ 3+ 3+ 3+ 2+
MAT1	- - - - -	- - - - -	- - - - -	- - - - -	- - - - -
XPG	nd nd nd nd nd	- 1+ 2+ 2+ -	- 1+ 2+ 2+ 1+	- 2+ 3+ 3+ 2+	- 2+ 3+ 3+ 2+

*Relative post-irradiation recruitment and dispersal kinetics of various NER and TFIIH factors at localized DNA damage sites were examined in XP-B (XP33BR), XP-B/CS fibroblasts from mild symptom patients (XPCS1BA, XPCS2BA), and in fibroblasts from severe symptom patients (XP181MA, XP183MA). Scores of -, 1+, 2+ and 3+ respectively represent < 20, 20-40, 40-60 and 60-80% of the cognate factor-positive foci in the cell population. The percentage are calculated based on foci and cell counts from more than three fields. “nd” indicates “not done”.