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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Mol Cancer Res. 2012 Jul 13;10(11):1440–1450. doi: 10.1158/1541-7786.MCR-12-0158

Figure 2. In vitro growth properties in C8161 siGRM1 human melanoma cells.

Figure 2

(A.) MTT cell viability/proliferation assays showing decreased viability and proliferation in C8161 human melanoma cells with suppressed GRM1 expression by the ecdysone regulated system in the presence of 10 μM PonA. (B.) C8161 pVgRXR siGRM1 cells treated with 10 μM PonA showing increased cleavage of PARP an indicator of apoptosis but not in control C8161 pVgRXR cells. Equal loading was shown by levels of α-Tubulin. NT - No treatment, Veh - Vehicle- DMSO, PonA - Ponasterone A.