Table 3. DLCO, DLNO, DM, VC, VA, DLNO/VA, DLNO/DLCO, and SaO2 in response to exercise.
| AA | AT/TT | |||
|---|---|---|---|---|
|
|
|
|||
| Rest | Peak Exercise | Rest | Peak Exercise | |
| DLCO (mL/min/mmHg) | 21± 8 | 27±10 | 17±7 | 24±11 |
| DLNO (mL/min/mmHg) | 70±25 | 82±28 | 53±22 | 74±35 |
| DM (mL/min/mmHg) | 34±12 | 38±13 | 25±10 | 35±16 |
| Vc (mL) | 54±25 | 97±43 | 50±29 | 71±43 |
| VA (mL) | 2215±481 | 2364±679 | 2216±734 | 2127±682 |
| DLNO/VA | 31±7 | 35±7 | 25±8 | 33±7† |
| DLNO/DLCO | 3.3±.3 | 3.0±.2 | 3.1±.4 | 3.1±.2 |
| SaO2 (%) | 96±1 | 95±4 | 96±2 | 92±7 |
Values are mean±SD, DLCO= diffusing capacity of the lung for carbon monoxide, DLNO= diffusing capacity of the lung for nitric oxide, DM= alveolar-capillary membrane conductance. VC= pulmonary capillary blood volume, VA= alveolar volume, DLNO/VA= diffusing capacity of the lung for nitric oxide corrected for alveolar volume, SaO2= oxygen saturation. AA genotype= homozygous for SCNN1A resulting in alanine at amino acid 663; AT/TT genotype= at least one copy of SCNN1A resulting in threonine at amino acid 663. No significant differences were seen between genotypes.
†
=p<0.05 from rest to peak exercise within group.