Figure 4.
Images of Zn(II) release during GSIS in a 12 week old control (A) versus a STZ-treated mouse (B). The color overlay represents the tissue areas where a contrast enhancement was observed after a bolus injection of GdDOTA-diBPEN and glucose. The colored image overlays reflect the same changes as noted in Fig. 3. The arrows refer to F = fundus stomach, S = spleen, K = kidneys. The images were collected from the same mouse before and 4 days after a single high-dose treatment of STZ. From ref. [64] copyright 2011.