Figure 1.

A Comparison of endpoints before and after CAE^SM exposure.

Notes: Graphs show mean values (±SD) for the three endpoints in the total population, as well as for subjects with MBA_I > 0.2 (severe dry eye), and MBA_I < 0.2 (moderate dry eye). (A) Decrease in MBA was limited to subjects with MBA_I > 0.2. (B) Compensatory increases in blink rates were primarily seen in subjects with MBA_I <0.2. (C) All subjects experienced similar increases in corneal staining.

Abbreviations: CAE^SM, controlled adverse environment; MBA, mean break-up area; MBA_I, initial mean break-up area.