Table 1.
Overview of study protocol
| Dry eye metrics | Pre-CAESM (baseline) | 90 minute exposure to controlled adverse environment (CAESM) | Post-CAESM | 30 minutes post-CAESM |
|---|---|---|---|---|
| Video-based assessments | ||||
| Break-up area (MBA) | ✓ | ✓ | ✓ | ✓ |
| Blink rate (inter-blink interval) | ✓ | ✓ | ✓ | ✓ |
| Palpebral fissure width | ✓ | ✓ | ✓ | ✓ |
| Conjunctival redness | ✓ | ✓ | ✓ | ✓ |
| Tear film break-up time | ✓ | ✓ | ✓ | ✓ |
| Corneal fluorescein staining | ✓ | ✓ | ✓ | ✓ |
| Subject-reported ocular discomfort (at 5 minute intervals) | ✓ | ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ | ✓ | ✓ |
Note: Tests were conducted in the order shown at the three time points.
Abbreviation: MBA, mean break-up area.