A: Fluorescence microscopy revealed lower protein expression of B2M in MN-siB2M–treated grafts compared with control probe grafts 2 weeks after adoptive transfer (green, insulin; red, B2M; blue, DAPI nuclear stain; magnification bar = 50 μm). B: Fluorescence microscopy showed markedly lower CD8+ T-cell infiltration in MN-siB2M–treated grafts compared with control islet grafts 2 weeks after adoptive transfer (green, insulin; red, CD8; blue, DAPI nuclear stain; magnification bar = 40 μm). C: Western blot analysis confirmed notably lower B2M protein expression in MN-siB2M–treated islet grafts compared with control grafts. (A high-quality digital representation of this figure is available in the online issue.)