FIG. 4.
Nrf2 activation reduces lipid deposition and lipogenic gene expression in WAT of Lepob/ob mice. A: TG and FFA levels in epididymal pad from 8-week-old male mice (n = 4 to 8). B: Total RNA was extracted and gene expression was analyzed by quantitative real-time PCR from epididymal pad of 8-week-old male mice (n = 5 to 8). $P < 0.05, Keap1-KD mice compared with WT mice; #P < 0.05, OB mice compared with WT mice; *P < 0.05, OBKeap1-KD mice compared with OB mice. Irs, insulin receptor substrate; LPL, lipoprotein lipase; MGL, monoacylglycerol; HSL, hormone sensitive lipase.