FIG. 5.
Enhanced Nrf2 activity reduced insulin signaling molecules and suppressed lipogenic gene expression in epididymal WAT in Lepob/ob mice. Immunoblot analysis of SCD-1, Ser79-phospholylated-Acetyl-CoA carboxylase (p-ACC-1), total ACC-1, PPARγ (A), ser473-phospholylated-Akt (p-Akt), total Akt (Akt), Nqo1 (B) in epididymal WAT from 8-week-old mice is shown. C: Immunoblot analysis of Nrf2 in MEFs from four types of mice. $P < 0.05, Keap1-KD mice compared with WT mice; #P < 0.05, OB mice compared with WT mice; *P < 0.05, OBKeap1-KD mice compared with OB mice.