Fig. 2.

Effect of different doses of polyphenolic extract of C. copticum on naloxone-induced jumping. Morphine dependent mice (n=6) received different doses of polyphenolic extract of C. copticum or vehicle via oral route 90 min prior to naloxone (5 mg/kg, i.p.) and number of jumpings were recorded during a 30 min period. Clonidine (0.2 mg/kg, p.o.) was used as standard drug. Data are mean ± S.E.M. of 6 mice in each group. * P<0.05 compared with control group (ANOVA and Duncan).