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. 2012 Nov 3;135(11):3311–3319. doi: 10.1093/brain/aws257

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© The Author (2012). Published by Oxford University Press on behalf of the Guarantors of Brain

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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An intraneuronal alkalosis is triggered after asphyxia and suppressed by graded restoration of normocapnia. The experimental changes in inhaled CO₂ and O₂ are schematically shown above the recordings. (A) Two-photon in vivo measurements of intracellular pH changes (mean ΔpH indicated by black line) in 40 layer 2/3 pyramidal neurons shown in colour from five Day 6–7 rat pups. Inset shows BCECF-loaded neurons. Scale bar = 20 µm. (B) Intracellular ΔpH in 41 neurons from five rat pups in the graded restoration of normocapnia paradigm.