Table 3.
Chemical parameters for PBPK models for PFOA and PFOS in pregnant and lactating women, fetus, and infant.
| PFOA | PFOS | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Parameter | mother | fetus | infant | mother | fetus | infant |
| Free fraction of chemical in plasma (Free) | 0.02 | 0.02 | 0.02 | 0.025 | 0.025 | 0.025 |
| Volume of distribution (Vdc; infant only, scaled to BWKid) | - | - | 0.17 | - | 0.22 | |
| Renal resorption Parameters | ||||||
| transporter maximum, Tmc (ug/h/kg0.75) | 10 | - | - | 3.5 | - | - |
| affinity constant, Kt (ug/L) | 0.055 | - | - | 0.023 | - | - |
| Partition Coefficients | ||||||
| Gut:plasma (Pgut) | 0.05 | - | - | 0.57 | - | - |
| Liver:plasma (Pliv) | 2.2 | - | - | 3.72 | - | - |
| Kidney: plasma (Pkid) | 1.05 | - | - | 0.8 | - | - |
| Fat: plasma (Pfat) | 0.04 | - | - | 0.13 | - | - |
| Mammary Tissue: plasma (Pmam; gestation only) | 0.13 | - | - | 0.16 | - | - |
| Rest of body tissues: plasma (Ptis) | 0.12 | 0.12 | - | 0.20 | 0.20 | - |
| Placenta:Plasma (Ppla) | 0.28 | - | - | 0.41 | - | - |
| Skin: plasma (PSk) | 0.1 | - | - | 0.29 | - | - |
| Mammary tissue:plasma (PMam; gestation only) | 0.13 | - | 0.16 | - | - | |
| Milk: plasma (PMilk; lactation only) | 0.038 | - | - | 0.0122 | - | - |
| Uptake/Elimination Rate Constants | ||||||
| urinary elimination rate constant, kurinec (/h/kg-0.25); keliml for infant (/h) | 0.1 | - | 0.005 | 0.005 | - | 0.001 |
| Placental transfer (gestation only) | ||||||
| mother to fetus, ktrans1C (L/h/kg0.75) | 0.46 | - | - | 0.46 | - | - |
| fetus to mother, ktrans2C (L/h/kg0.75) | - | 0.46 | - | - | 1.01 | - |
| Amniotic fluid transfer (gestation only) | ||||||
| fetus to fluid, ktrans3C (L/h/kg0.75) | - | 0.008 | - | - | 0.006 | - |
| fluid to fetus, ktrans4C (L/h/kg0.75) | - | 0.001 | - | - | 0.001 | - |