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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Toxicol Environ Health A. 2013;76(1):25–57. doi: 10.1080/15287394.2012.722523

Table 3.

Chemical parameters for PBPK models for PFOA and PFOS in pregnant and lactating women, fetus, and infant.

PFOA PFOS

Parameter mother fetus infant mother fetus infant
Free fraction of chemical in plasma (Free) 0.02 0.02 0.02 0.025 0.025 0.025
Volume of distribution (Vdc; infant only, scaled to BWKid) - - 0.17 - 0.22
Renal resorption Parameters
transporter maximum, Tmc (ug/h/kg0.75) 10 - - 3.5 - -
affinity constant, Kt (ug/L) 0.055 - - 0.023 - -
Partition Coefficients
Gut:plasma (Pgut) 0.05 - - 0.57 - -
Liver:plasma (Pliv) 2.2 - - 3.72 - -
Kidney: plasma (Pkid) 1.05 - - 0.8 - -
Fat: plasma (Pfat) 0.04 - - 0.13 - -
Mammary Tissue: plasma (Pmam; gestation only) 0.13 - - 0.16 - -
Rest of body tissues: plasma (Ptis) 0.12 0.12 - 0.20 0.20 -
Placenta:Plasma (Ppla) 0.28 - - 0.41 - -
Skin: plasma (PSk) 0.1 - - 0.29 - -
Mammary tissue:plasma (PMam; gestation only) 0.13 - 0.16 - -
Milk: plasma (PMilk; lactation only) 0.038 - - 0.0122 - -
Uptake/Elimination Rate Constants
urinary elimination rate constant, kurinec (/h/kg-0.25); keliml for infant (/h) 0.1 - 0.005 0.005 - 0.001
Placental transfer (gestation only)
mother to fetus, ktrans1C (L/h/kg0.75) 0.46 - - 0.46 - -
fetus to mother, ktrans2C (L/h/kg0.75) - 0.46 - - 1.01 -
Amniotic fluid transfer (gestation only)
fetus to fluid, ktrans3C (L/h/kg0.75) - 0.008 - - 0.006 -
fluid to fetus, ktrans4C (L/h/kg0.75) - 0.001 - - 0.001 -