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Criteria for distinguishing low-risk and high-risk well-differentiated carcinoma based on the AGES (age, grade, extrathyroid extent, and size) classification system.
| Low | High |
|---|---|
| Women < 50 years | Women ≥ 50 years |
| Men < 40 years | Men ≥ 40 years |
| Well-differentiated tumor | Poorly differentiated tumor (tall cell, columnar cell, or oxyphilic variants) |
| Tumor < 4 cm in diameter | Tumors ≥ 4 cm in diameter |
| Tumor confined to thyroid | Local invasion |
| No distant metastases | Distant metastases |
