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. Author manuscript; available in PMC: 2012 Nov 20.
Published in final edited form as: Dev Biol. 2011 Apr 3;354(1):134–142. doi: 10.1016/j.ydbio.2011.03.027

Fig. 6.

Fig. 6

Excessive tbx5 positive anterior-lateral plate mesoderm formed in cdx-deficient embryos requires additional inhibition of the retinoic acid pathway in order to adopt cardiac fate and form nkx2.5 expressing cardiac cells. Shown are wildtype, cdx4−/− and cdx1/4 deficient embryos analyzed at 15-somite stage after treatment with the retinoic acid inhibitors DEAB, Ro-41-5253, or DMSO (vehicle) as a control. cdx-dose-dependent effects are observed with both inhibitors.