Table 5.
Deregulated miRNAs (n = 19) consistently reported in profiling studies (lung SCC tissue versus normal)
|
Direction of expression |
miRNA namea |
No. of studies with same direction (reference) |
Total number of tissue samples tested |
Subset of studies with fold change |
|||
|---|---|---|---|---|---|---|---|
| No. of studies | Total number of tissue samples tested | Mean fold change | Range | ||||
| Up-regulated |
miR-210 |
4 (24,26,29,30) |
247 |
1 |
30 |
2.37 |
- |
| |
miR-203 |
3 (24,26,30) |
217 |
0 |
- |
- |
- |
| |
miR-205 |
3 (26,29,30) |
176 |
1 |
30 |
2.99 |
- |
| |
miR-21 |
3 (29,30,33) |
116 |
2 |
38 |
2.53 |
1.74 - 3.31 |
| |
miR-31 |
3 (26,29,33) |
106 |
2 |
38 |
4.42 |
1.58 - 7.26 |
| |
miR-182 |
2 (24,26) |
139 |
0 |
- |
- |
- |
| |
miR-200c |
2 (24,29) |
101 |
1 |
30 |
1.66 |
- |
| |
miR-18a |
2 (26,33) |
76 |
1 |
8 |
2.24 |
- |
| Down-regulated |
miR-126 |
4 (26,29,31,33) |
112 |
3 |
44 |
0.18 |
0.00 - 0.42 |
| |
miR-30a |
4 (26,29,31,33) |
112 |
3 |
44 |
0.28 |
0.11 - 0.53 |
| |
miR-30d |
3 (29,31,33) |
44 |
3 |
44 |
0.33 |
0.22 - 0.54 |
| |
miR-195 |
2 (26,29) |
98 |
1 |
30 |
0.53 |
- |
| |
miR-497 |
2 (26,29) |
98 |
1 |
30 |
0.66 |
- |
| |
miR-126* |
2 (30,33) |
86 |
1 |
8 |
0.16 |
- |
| |
miR-143 |
2 (30,33) |
86 |
1 |
8 |
0.24 |
- |
| |
miR-145 |
2 (26,33) |
76 |
1 |
8 |
0.48 |
- |
| |
miR-451 |
2 (29,33) |
38 |
2 |
38 |
0.37 |
0.22 - 0.53 |
| |
miR-30b |
2 (29,33) |
38 |
2 |
38 |
0.50 |
0.48 - 0.53 |
| miR-101 | 2 (31,33) | 14 | 2 | 14 | 0.34 | 0.29 - 0.39 | |
a The asterisk is part of the miRNA nomenclature system and is not linked to any footnote specific to this table. SCC, squamous cell carcinoma.