Table 6.
Deregulated miRNAs (n = 7) consistently reported in profiling studies (lung ADC tissue versus normal)
|
Direction of expression |
miRNA name |
No. of studies with same direction (reference) |
Total number of tissue samples tested |
Subset of studies with fold change |
|||
|---|---|---|---|---|---|---|---|
| No. of studies | Total number of tissue samples tested | Mean fold change | Range | ||||
| Up-regulated |
miR-210 |
3 (22,30,32) |
376 |
2 |
246 |
1.96 |
1.75 - 2.17 |
| |
miR-182 |
2 (22,32) |
246 |
2 |
246 |
2.03 |
1.85 - 2.22 |
| |
miR-31 |
2 (22,32) |
246 |
2 |
246 |
1.83 |
1.60 - 2.05 |
| |
miR-21 |
2 (30,32) |
170 |
1 |
40 |
2.56 |
- |
| Down-regulated |
miR-218 |
2 (22,32) |
246 |
2 |
246 |
0.61 |
0.60 - 0.62 |
| |
miR-145 |
2 (30,32) |
170 |
1 |
40 |
0.38 |
- |
| miR-126 | 2 (30,32) | 170 | 1 | 40 | 0.46 | - | |
ADC, adenocarcinoma/adenosquamous carcinoma.