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(A-C) LPS caused a significant acute systemic inflammatory response as early as 6 hours. Administration of UC-MSCs reduced pro-inflammatory cytokines at each time point. (D) LPS also caused an increase of anti-inflammatory cytokine IL-10, but this change was not altered by intravenous administration of UC-MSCs (*, p < 0.05 compared with healthy controls; #, p < 0.05 comparing LPS plus UC-MSCs with LPS alone).
