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. 2012 Nov 20;7(11):e50028. doi: 10.1371/journal.pone.0050028

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© 2012 Batra et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Semilogarithmic plot of rhTIMP-1 (open circles) or PEG_20K-TIMP-1 (filled triangles) in plasma versus time show that half-life is markedly extended for the PEGylated protein. Mice (6 per group) were injected intraperitoneally with 2 mg/kg rhTIMP-1 or PEG_20K-TIMP-1 and then blood samples were collected serially at the indicated time points; each data point represents the average and standard error for measurements from 3 mice. The dotted and solid curves show best fits to the equation for two phase exponential decay for rhTIMP-1 and PEG_20K-TIMP-1, respectively.