Figure 6. PEG_20K-TIMP-1 activity in cancer cell invasion assay.

(A) Pictures of representative fields from filters with fixed and stained cells are shown for control and PEG_20K-TIMP-1-treated wells. (B) Graph shows a concentration dependent decrease in the number of invasive MDA-MB-231 cells in the presence of 50 or 500 nM of unmodified or PEGylated rhTIMP-1 in Matrigel transwell assays. Plotted values represent average and standard error from triplicate filters; cells were counted from entire filters using image processing software. *, p<0.01.