Table 1. Overview of ion channels affected by AMPK activation. Shown is a list of the ion channels reported to date to respond to AMPK activation. It is summarized how AMPK activation affects the individual ion channels and what the molecular background for the observed regulation is.
| Inhibitory effects of AMPK | |||
|---|---|---|---|
| Ion channel |
AMPK effect |
Mode of action |
References |
| BKCa |
Reduction in current amplitude |
Direct channel phosphorylation |
23
|
| CFTR |
Decreased open probability |
Direct channel phosphorylation (S768) |
20
,
19
,
21
|
| ENaC |
Reduction in cell surface expression |
Activation of Nedd4–2-mediated endocytosis |
29
,
28
|
| KCa3.1 |
Reduction in current amplitude |
? |
27
|
| Kir2.1 |
Reduction in cell surface expression |
Activation of Nedd4–2-mediated endocytosis |
33
|
| Kir6.2 |
Reduction in current amplitude |
Direct channel phosphorylation (S385) |
45
,
44
|
| Kv7.1 |
Reduction in cell surface expression |
Activation of Nedd4–2-mediated endocytosis |
32
,
31
,
34
|
| TASK-3 |
Reduction in current amplitude |
? |
25
|
| TREK-1 |
Reduction in current amplitude |
Involves the phosphorylation sites S300 and S333 |
26
|
| TREK-2 | Reduction in current amplitude | Involves the phosphorylation sites S326 and S359 | 26 |
| Stimulatory effects of AMPK | |||
|---|---|---|---|
| Ion channel |
AMPK effect |
Mode of action |
References |
| Kir6.2 |
Increased open probability |
? |
40
|
| Kir6.2 |
Increased surface expression |
? |
43
,
42
|
| Kv2.1 |
Hyperpolarizing shifts in the current-voltage relationship for channel activation and inactivation |
Direct channel phosphorylation (S440) |
38
|
| Nav1.5 | Slowing of open-state inactivation and a hyperpolarizing shift in the voltage-activation curve | ? | 37 |