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Figure 4. CrossMab principle. Starting from a conventional IgG antibody correct chain association in a bispecific heterodimeric antibody can be achieved using the KiH technology to enforce correct heavy chain heterodimerization in combination with domain crossover of light chain domains to enforce correct light chain association. The three possible light chain domain crossovers are depicted: Fab domain crossover on the left, VH-VL domain crossover on the right and CH1-CL crossover on the top.
