Figure 6. HER2- and VEGF-binding dual acting antibody (DAF)^62,63 shown as superposition of the complex structures with HER2 (PDB:3bdy) and with VEGF-A (PDB:3be1). The picture illustrates that HER2 (red) interacts mainly with the heavy chain of the antibody (dark blue), whereas VEGF-A (orange) interacts almost exclusively with the light chain (light blue). There are no significant interactions within the unrelated pairs HC-VEGF and LC-HER2. The Fab of 3be1 has been omitted for clarity since both Fabs exhibit an almost identical structure.