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Figure 3. Comparison of affinity gains from the standard NNS optimization approach and the TiAM method. (A) The affinity improvement over the ICM10064 parent antibody for all optimized VLCDR3 variants from the TiAM and NNS methods, respectively. (B) The affinity improvement over the ICM10088 parent antibody for all optimized VHCDR3 and VLCDR3 variants from the TiAM and NNS methods. Also plotted are the improvements conferred by performing the TiAM approach in VLCDR 1 and 2 and VHCDR 1 and 2.
