Table 1. Characteristics of the antibodies in the affinity maturation sequence analysis data set.
| Antibody (CDRs targeted) | Variant amino acids analyzed | Antigen type | VH Germline | VH CDR3, a.a. length | VL Germline | VL CDR3, a.a. length |
|---|---|---|---|---|---|---|
|
1 (H3) |
53 |
Secreted protein |
VH1 1–69 |
17 |
Vλ1 1b |
11 |
|
2 (H3) |
445 |
Secreted protein |
VH1 1–69 |
19 |
Vλ1 1b |
11 |
|
3 (H3) |
73 |
Secreted protein |
VH1 1–46 |
18 |
Vλ3 3l |
13 |
|
4 (H3) |
75 |
Secreted protein |
VH1 1–69 |
16 |
Vλ1 1b |
11 |
| 5 (H3&L3) |
187 |
Receptor |
VH3 3–23 |
19 |
Vλ3 3r |
11 |
| 6 (H3&L3) |
346 |
Receptor |
VH5 5–51 |
12 |
Vλ3 3l |
9 |
|
7 (H3&L3) |
1232 |
Receptor |
VH1 1–24 |
11 |
Vλ1 1e |
11 |
| 8 (H3&L3) |
266 |
Receptor |
VH3 3–23 |
9 |
Vλ3 3r |
10 |
| 9 (H3&L3) |
394 |
Receptor |
VH1 1–24 |
12 |
Vλ1 1c |
11 |
| 10 (H3&L3) |
341 |
Receptor |
VH3 3–30.5 |
13 |
Vλ3 3l |
10 |
|
11 (H3) |
28 |
Secreted protein |
VH3 3–11 |
10 |
Vκ1 L12 |
9 |
|
12 (H3&L3) |
318 |
Secreted protein |
VH1 1–18 |
10 |
Vκ1 L12 |
9 |
|
13 (H3&L3) |
102 |
Secreted protein |
VH3 3–32 |
12 |
Vλ2 2a2 |
9 |
|
14 (H3&L3) |
405 |
Secreted protein |
VH1 1–02 |
10 |
Vλ3 3h |
10 |
|
15 (H3&L3) |
216 |
Secreted protein |
VH1 1–02 |
12 |
Vλ1 1e |
10 |
| 16 (H3&L3) |
225 |
Receptor |
VH3 3–23 |
12 |
Vλ2 2a2 |
7 |
| 17 (H3&L3) |
513 |
Receptor |
VH3 3–11 |
7 |
Vλ3 3m |
11 |
|
18 (H3&L3) |
88 |
Receptor |
VH3 3–30.5 |
13 |
Vλ1 1e |
11 |
|
19 (H3&L3) |
310 |
Receptor |
VH3 3–23 |
21 |
Vλ1 1b |
11 |
|
20 (H3&L3) |
178 |
Receptor |
VH3 3–23 |
7 |
Vλ3 3l |
11 |
| 21 (H3&L3) | 300 | Receptor | VH3 3–23 | 8 | Vλ2 2a2 | 11 |