Table 2. Dose-dependent tumor growth delay with U87 tumors treated with CE-355621.
Sample | Time to reach 1000 mm3 (days) |
---|---|
Vehicle |
6.2 ± 0.2 |
25 μg CE-355621 |
9.9 ± 0.2*** |
100 μg CE-355621 |
16.1 ± 1.1*** |
200 μg CE-355621 | 22.3 ± 0.4*** |
p < 0.001(by Student’s t-test). Increasing doses of CE-355621 induce progressively longer tumor growth delay in U87MG tumors. The size of each tumor in Figure 7A was measureon c-Met in GTL-16 xenograft tumorsd every 2–3 d and the time to reach 1000 mm3 (days) from the start of treatment was determined. Values are means ± SEM.