Table 1. Non compartmental pharmacokinetic parameter estimates (mean ± SD) following a single SC bolus of HAE1 or HAE2 to juvenile cynomolgus monkeys.
| Dose (mg/kg) |
CL/F (mL/day/kg) |
Vss/F (mL/kg) |
t1/2, elim (day) |
|---|---|---|---|
| HAE1 | |||
| 7.5 |
7.9 ± 4.3 |
75 ± 10 |
6.8 ± 4.1 |
| 15 |
6.5 ± 5.1 |
68 ± 16 |
7.8 ± 42 |
| 30 |
4.4 ± 0.9 |
62 ± 7.7 |
7.1 ± 4.1 |
| 50 |
5.1 ± 1.7 |
63 ± 7.6 |
8.4 ± 4.7 |
| 75 |
3.1 ± 0.5 a |
42 ± 4.3 b |
6.6 ± 4.7 |
| 100 |
2.5 ± 0.4 b |
37 ± 2.9 b |
9.1 ± 5.1 |
| 200 |
2.8 ± 0.6 b |
52 ± 4.9 b |
10 ± 4.5 |
| 250 | 3.4 ± 0.8 a | 50 ± 10 b | 8.6 ± 6.0 |
| HAE2 | |||
|---|---|---|---|
| 30 |
3.0 ± 1.1 d |
46 ± 10 d |
9.0 ± 4.9 |
| 50 |
3.2 ± 0.5 d |
51 ± 6.2 d |
7.0 ± 4.0 |
| 100 |
1.9 ± 0.2 c |
31 ± 4.5 c, d |
7.6 ± 2.9 |
| 250 | 2.4 ± 0.3 c | 38 ± 3.7 c, d | 12 ± 4.3 |
CL/F, clearance; t1/2,elim, elimination half life; Vss/F, volume of distribution at steady state. Note: n = 6/group. ap ≤ 0.05 compared with HAE1 7.5 and 15 mg/kg dose groups. bp ≤ 0.05 compared with HAE1 7.5, 15, 30 and 50 mg/kg dose groups. cp ≤ 0.05 compared with HAE2 30 and 50 mg/kg dose groups. dp ≤ 0.05 compared with HAE1 at equivalent dose.