Table 2. Pharmacodynamic parameters (mean ± SD) following a single SC dose of HAE1 or HAE2 to juvenile cynomolgus monkeys.
| Dose (mg/kg) |
Bsl Avg IgE (ng/mL) |
IgEmax/Bsl IgE Ratio |
IgElast/Bsl IgE Ratio |
|---|---|---|---|
| HAE1 | |||
| Control |
656 ± 707 |
7.5 ± 7.6 |
2.4 ± 1.9 |
| 7.5 |
1310 ± 1290 |
30 ± 33 a |
5.3 ± 9.7 |
| 15 |
2730 ± 3850 |
34 ± 32 a |
4.3 ± 5.4 |
| 30 |
585 ± 798 |
26 ± 15 a |
6.5 ± 10 |
| 50 |
3040 ± 5190 |
13 ± 13 |
0.9 ± 0.3 |
| 75 |
2510 ± 3380 |
31 ± 28 a |
7.6 ± 11 |
| 100 |
2790 ± 4730 |
43 ± 43 a |
32 ± 50 |
| 200 |
623 ± 355 |
35 ± 25 a |
13 ± 14 |
| 250 | 1250 ± 864 | 13 ± 8.5 | 5.6 ± 8.8 |
| HAE2 | |||
|---|---|---|---|
| Control |
1830 ± 2630 |
1.9 ± 0.7 |
1.0 ± 0.7 |
| 30 |
4680 ± 7320 |
89 ± 68 b, c |
21 ± 39 |
| 50 |
1730 ± 1300 |
58 ± 24 b, c |
18 ± 40 |
| 100 |
5120 ± 6410 |
112 ± 136 b |
15 ± 27 |
| 250 | 4190 ± 6690 | 30 ± 20 b | 20 ± 22 a |
Bsl Avg IgE, mean baseline total IgE concentration; IgElast/Bsl IgE, last observed total IgE concentration divided by Bsl Avg IgE; IgEmax/Bsl IgE, maximum observed total IgE concentration divided by Bsl Avg IgE. Note: Data represent the mean (±SD) of n = 6/group. ap < 0.05 compared with Placebo. bp < 0.0001 compared with Placebo. cp < 0.05 compared with HAE1 at equivalent dose.