Figure 1. Correlation of antibody clearance values measured in humans and cynomolgus monkeys (ρ = 0.74, n = 16). For our analyses, antibody doses were chosen that were believed to saturate any target-dependent clearance. The solid line is a linear regression fit of the logarithm of human clearance to the logarithm of cynomolgus monkey clearance [log(Human clearance) = 0.0123 + 0.744 * log(Cyno clearance)]. For most antibodies shown, human clearance is about two-fold slower than the corresponding cynomolgus monkey clearance. By contrast, for anti-NRP1 the clearance in human (9.2 mL/day/kg) is ~2-fold faster than the clearance in cynomolgus monkey (4.3 mL/day/kg).