Figure 2. Clearance values of antibodies (n = 52) in cynomolgus monkeys. Individual animal data and geometric mean values (red bars) are shown from dose groups where contribution of any specific clearance to the reported clearance was assumed to be negligible. Humanized (circle), human (square), synthetic human phage derived (triangle), and chimeric (diamond) antibodies are shown. Filled symbols indicate antibodies with a λ light chain (mAbs 2, 20, 29, 43), all others have a κ light chain. IgG4 isotype antibodies having the hinge-stabilizing mutant S228P are colored blue (mAbs 9, 24), all others are IgG1 isotype. Red symbol indicates an afucosylated antibody (mAb 3). Aglycosylated antibodies obtained via replacement of Asn297 with Ala are colored orange (mAbs 13, 14, 20, 33, 37, 46). Antibodies with Fc amino acid substitutions to modulate FcγR binding are colored green (mAbs 1, 19, 40).