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Role of genetics in tuberculosis susceptibility. The vitamin D receptor (VDR) has an integral role in the tuberculosis immune response through its binding with vitamin D to induce antimicrobial function via LL-37. Several polymorphisms in the VDR gene have also been implicated in tuberculosis susceptibility. Abbreviations: MTB, Mycobacterium tuberculosis; RXR, retinoid X receptor; TLR, Toll-like receptor; VD, vitamin D.
