Figure 3.

Splenocytes from EP2^−/− mice exhibit increased antigen-specific proliferation in response to mycobacterial complete soluble antigen (CSA). Splenocytes were isolated from uninfected and Mycobacterium tuberculosis H37Rv–infected EP2^−/− and C57BL/6 (wild-type) mice and stimulated with different concentrations of CSA. Proliferation was analyzed after 72 hours using tritiated thymidine. Data shown here is representative of 3 independent experiments with 3 mice in each group and represents the mean ± standard deviation values.