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. 2012 Nov 20;7(11):e49456. doi: 10.1371/journal.pone.0049456

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Median pO₂ values (A), percentage of hypoxic fraction (B), and mean blood volume (C) in the control and rapamycin treated SCC tumors. The values are average of 5 or 6 mice and error bars represent standard deviations. Oxygen delivery per unit blood volume (D) was calculated by dividing tumor pO₂ by blood volume. * p<0.05 as compared with control, ** p<0.01 as compared with control, † p<0.05 as compared with rapamycin day 8, †† p<0.005 as compared with rapamycin day 8.