Figure 1.

Preliminary modeling of administration of primaquine together with ACTs in a range of transmission settings. A simulation of adding primaquine to ACT first line treatment versus ACTs only in a seasonal setting. In this simulation 80% of clinical cases are treated with ACT alone or ACT-PQ. Primaquine is assumed to reduce the duration of infection by 78% and the level of infectiousness by 67% in treated patients compared to those treated with ACT alone. In a low transmission scenario, adding PQ to the treatment of clinical cases causes a higher relative reduction than in higher transmission scenarios. Ro differs between settings. Migration is not allowed for. With the kind permission of Lucy Okell, Jamie Griffin & Azra Ghani. For further details, see reference [40] .