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. 2012 Nov 20;10(11):e1001427. doi: 10.1371/journal.pbio.1001427

Figure 6. Hypothetical mechanism of action of novel human-specific RNA, LOC389023.

Figure 6

(Top) In non-human primate, DPP10 transcripts are expressed by the RNA polymerase II complex from the DPP10-2 promoter (see text) that is tagged with H3K4me3. (Bottom) In human, there is specific gain of H3K4me3 signal particularly in the 5′ portion of the DPP10-2 promoter (see text), which is associated with a novel antisense RNA, LOC389023. This RNA recruits Polycomb 2(PRC2) and other transcriptional repressors in cis, thereby inhibiting expression of the sense transcript, DPP10.