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Syntheses of Glu‐ureido‐Lys(Ahx)-HBED-CC (6) and [Glu‐ureido‐Lys(Ahx)]2-HBED-CC (7). (a) Triphosgene, DIPEA, CH2Cl2, 0°C; (b) H-Lys(Alloc)-2CT-Resin, CH2Cl2; (c) Pd[P(C6H5)3]4, morpholine, CH2Cl2; (d) Fmoc-6-Ahx-OH, HBTU, DIPEA, DMF; (e) 20% piperidine, DMF; (f) hexafluoroisopropanol/CH2Cl2; (g) HBED-CC-TFP ester, DIPEA, DMF; (h) TFA; (i) (HBED-CC)TFP2 diester, DIPEA, DMF; (j) TFA.
