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. 2012 Jun 6;2:23. doi: 10.1186/2191-219X-2-23

Table 1.

Analytical and PSMA-binding data

Ga-peptide complexes m/za m/zcalculated as [M + H]+ AnalyticalHPLC retention (min)b Affinity-related IC50determined in enzyme-based assay (nM)c Affinity-related IC50determined in cell-based assay (nM)c
[Ga]6
947.4257
947.4250
3.1
9.0 ± 1.1
12.1 ± 2.1
[Ga]7 1,361.6387 1,361.6364 3.1 2.1 ± 1.4 3.8 ± 1.8

aHigh-resolution mass spectrometry data of the free ligands ([M + H]+); bcompounds were labeled with 68Ga; runs were performed using a linear A-B gradient (0% B to 100% B in 6 min) at a flow rate of 4 mL/min; solvent A was 0.1% aqueous TFA, and solvent B was MeOH; ccompounds were complexed with natGa.