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. Author manuscript; available in PMC: 2012 Nov 21.
Published in final edited form as: Annu Rev Immunol. 2010;28:445–489. doi: 10.1146/annurev-immunol-030409-101212

Figure 2.

Figure 2

Networks of transcription factors for Th cell differentiation. Critical transcription factors involved in Th1, Th2, and Th17 differentiation and the relationships among these factors are shown. The cell fate of each Th lineage is determined by many transcription factors, including master regulators and STAT family proteins. There are collaborations and positive regulations among the transcription factors during Th cell differentiation and lineage-specific cytokine production. Some factors negatively regulate expression or function of transcription factors of other Th lineages.