Table 3.

Gene x Environment Interaction:genes altered by MB/PQin α-syn-Tg

Accession	Fold change	Gene title	Gene symbol	Functional Group
NM_145990	−2.35	CDK5 regulatory subunit associated protein 2	Cdk5rap2	Cell differentiation
NM_007865	−1.82	Delta-like 1 (Drosophila)	Dll1
NM_008380	−1.80	Inhibin beta-A	Inhba
NM_008711	−1.68	Noggin	Nog
NM_010894	−1.33	Neurogenic differentiation 1	Neurod1
NM_009170	−1.33	Sonic hedgehog	Shh
NM_008553	−1.26	Achaete-scute complex homolog 1 (Drosophila)	Ascl1
NM_008782	−1.24	Paired box gene 5	Pax5
NM_010275	−1.25	Glial cell line derived neurotrophic factor	Gdnf	Growth factors
NM_009505	−1.33	Vascular endothelial growth factor A	Vegfa
NM_007553	−1.28	Bone morphogenetic protein 2	Bmp2
NM_007554	−1.25	Bone morphogenetic protein 4	Bmp4
NM_010077	−1.31	Dopamine receptor D2	Drd2	Synaptic transmission
NM_013503	−1.23	Dopamine receptor D5	Drd5
NM_013904	−1.64	Hairy/enhancer-of-split related with YRPW motif 2	Hey2	Transcription
NM_013905	−1.61	Hairy/enhancer-of-split related with YRPW motif-like	Heyl
NM_007889	−1.52	Dishevelled 3, dsh homolog (Drosophila)	Dvl3	Cell signaling
NM_001008533	−1.30	Adenosine A1 receptor	Adora1
NM_008744	−1.39	Netrin 1	Ntn1	Cell motility
NM_174991	−1.28	Brain-specific angiogenesis inhibitor 1	Bai1	Cell proliferation
NM_022312	−1.27	Tenascin R	Tnr	Cell adhesion
NM_013660	−1.26	Sema domain, Ig domain, transmembrane domain and short cytoplasmic domain, 4D	Semad4	Apoptosis
NM_009685	−1.38	Amyloid beta (A4) precursor protein-binding, family B,1	Apbb1	Cell cycle

Comparison of gene expression between mThy-α-synuclein transgenic mice treated with Maneb/Paraquat, with their corresponding non-transgenic littermates treated with saline. P<0.05 per Student’s t test. Bold italic fonts denote genes also affected by genetic background or pesticides independently.