Table 4.

Gene x Environment Interaction:genes altered by MB/PQin LRRK2-Tg

Accession	Fold Change	Gene title	Gene symbol	Functional Group
NM_145990	1.32	CDK5 regulatory subunit associated protein 2	Cdk5rap2	Cell differentiation
NM_178591	−1.37	Neuregulin 1	Nrg1
NM_025876	−1.32	CDK5 regulatory subunit associated protein 1	Cdk5rap1
NM_008380	−1.31	Inhibin beta-A	Inhba
NM_013627	−1.29	Paired box gene 6	Pax6
NM_010894	−1.26	Neurogenic differentiation 1	Neurod1
NM_009170	−1.24	Sonic hedgehog	Shh
NM_009871	−1.22	CDK5 regulatory subunit 1 (p35)	Cdk5r1
NM_007540	−1.24	Brain derived neurotrophic factor	Bdnf	Growth factors
NM_009505	−1.23	Vascular endothelial growth factor A	Vegfa
NM_007554	−1.23	Bone morphogenetic protein 4	Bmp4
NM_013904	−1.30	Hairy/enhancer-of-split related with YRPW motif 2	Hey2	Transcription
NM_008900	−1.26	POU domain, class 3, transcription factor 3	Pou3f3
NM_007488	−1.24	Aryl hydrocarbon receptor nuclear translocator 2	Artn2
NM_022312	−1.27	Tenascin R	Tnr	Cell adhesion
NM_010110	−1.21	Ephrin B1	Efnb1
NM_183171	−1.21	Fasciculation and elongation protein zeta 1 (zygin I)	Fez1
NM_174991	−1.37	Brain-specific angiogenesis inhibitor 1	Bai1	Cell proliferation
NM_010883	−1.21	Norrie disease (pseudoglioma)	Ndph
NM_203491	−1.24	Cholinergic receptor, muscarinic 2	Chrm2	Synaptic functions
NM_009599	−1.21	Acetylcholinesterase	Ache
NM_008744	−1.39	Netrin 1	Ntn1	Cell motility and migration

Comparison of gene expression between mThy-LRRK2(G2019) transgenic mice treated with Maneb/Paraquat, with their corresponding non-transgenic littermates with saline. P<0.05 per Student’s t test. Bold italic fonts denote genes also affected by genetic background or pesticides independently.