TABLE 2.
Title to come
| EC50 | Residues Common to All Agonistsa | Residues Unique to a Specific Liganda | |
|---|---|---|---|
| μM | |||
| LPA 18:1 | 0.014 | Arg3.28, Gln3.29, Gly3.30, Leu3.32, Asp3.33, Leu3.34, Trp4.64, Leu5.37, Arg5.38, Trp6.48, Lys7.36, Phe7.38, Leu7.39 | |
| OTP | 0.09 | Trp5.40, Leu6.55 | |
| NSC12404 | 9.5 | Thr2.64 | |
| GRI977143 | 3.3 | Trp5.40 | |
| H2L5547924 | 2.9 | Interacts with all common residues but some interactions are less favorable than with LPA or OTP | |
| H2L5828102 | 16.7 | Leu7.32, Thr2.64, Ser270 |
a
Residues predicted to be within 4.5 Å of the docked ligand.