Fig. 2.

Ifenprodil prolongs specific closed components. A, closed intervals observed in two records obtained from 2B receptors in the absence (CTR, 42,360 events) and presence of ifenprodil (IFN, 150 nM, 78,017 events). Probability density functions (thick lines) were calculated by fitting kinetic 5C4O state models to the displayed data; thin lines represent individual exponential components. Their time constants (τ, milliseconds) and areas (a, percentages) are given as insets. B, summary of closed time constants in the two conditions [CTR (gray), n = 31; IFN (blue), n = 6]. Average values for CTR are given in milliseconds below each component. **, p < 0.003 (Student's t test).