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. 2012 Dec;82(6):1030–1041. doi: 10.1124/mol.112.079624

Fig. 6.

Fig. 6.

Resveratrol induces S-phase accumulation, an effect abrogated by HDACIs. A, U937 cells were exposed to 50 μM resveratrol (RESV) with or without 1.5 μM vorinostat (Vor) for the indicated periods, after which flow cytometry was performed for analysis of cell-cycle distribution after PI staining. R, resveratrol; V, vorinostat. B and C, flow cytometry was performed to determine the S-phase-specific population with a Click-iT EdU CellCycle 488-red (7-aminoactinomycin D) assay kit (B) or apoptosis in the S-phase population (C). Values indicate the percentage of S-phase (EdU-positive) cells (B) or the percentage of apoptotic (annexin V-allophycocyanin-positive) cells in the S-phase (EdU-Alexa Fluor 488-positive) population (C). C, control; L, LBH-589.