Table 4.
Levels of baseline cardiovascular risk factors and their changes across baseline C-reactive protein categories.
| Men | Women | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Low CRP <1.0 mg/L (n=85) | Average CRP 1-3 mg/L (n=43) | High CRP >3 mg/L (n=15) | P value | Low CRP <1.0 mg/L (n=49) | Average CRP 1-3 mg/L (n=60) | High CRP >3 mg/L (n=24) | P value | ||
| Body mass index (kg/m2) | Baseline | 26±3 | 27±3 | 28±3 | 0.05 | 24±3 | 27±3 | 28±3 | <0.0001 |
| Change | -0.6±1 | -0.7±1 | -0.5±1 | 0.94 | -0.5±2 | -0.6±1 | -0.4±1 | 0.87 | |
| Percent body fat (%) | Baseline | 21±4 | 22±4 | 25±5 | 0.01 | 29±5 | 34±5 | 34±5 | <0.0001 |
| Change | -1.4±4 | -0.3±3 | -0.9±3 | 0.29 | -0.9±5 | -0.6±4 | 1.2±4 | 0.14 | |
| Waist circumference (cm) | Baseline | 94±9 | 97±9 | 100±9 | 0.03 | 80±9 | 87±8 | 89±8 | <0.001 |
| Change | -3.5±4 | -3.5±5 | -3.4±4 | 0.99 | -3.1±7 | -3.3±5 | -2.6±4 | 0.85 | |
| Systolic BP (mmHg) | Baseline | 114±10 | 113±14 | 112±11 | 0.90 | 112±13 | 119±14 | 110±13 | 0.01 |
| Change | -2±9 | 1.2±9 | 1±9 | 0.08 | -3±12 | -3±12 | 2±12 | 0.15 | |
| Diastolic BP (mmHg) | Baseline | 76±7 | 75±9 | 77±7 | 0.53 | 71±7 | 75±8 | 71±7 | 0.03 |
| Change | -0.9±7 | 0.5±7 | 1.3±7 | 0.37 | -2.4±7 | -2.3±7 | -1±6 | 0.66 | |
| LDL-C (mg/dL) | Baseline | 155±16 | 162±19 | 153±15 | 0.04 | 166±23 | 165±21 | 163±20 | 0.90 |
| Change | -5±25 | -8±26 | -7±22 | 0.89 | -11±24 | -8±22 | -1±27 | 0.26 | |
| HDL-C (mg/dL) | Baseline | 35±5 | 35±5 | 32±4 | 0.07 | 45±7 | 45±8 | 44±8 | 0.59 |
| Change | 0.1±5 | 1.4±5 | 1.4±5 | 0.36 | 0.7±8 | 1.0±8 | 1.2±6 | 0.96 | |
| Triglycerides (mg/dL) | Baseline | 171±71 | 157±62 | 166±48 | 0.54 | 139±76 | 160±64 | 176±65 | 0.07 |
| Change | -8±70 | -3±65 | 22±77 | 0.32 | -1±64 | -6±52 | 2±63 | 0.86 | |
| Fasting glucose (mg/dL) | Baseline | 97±9 | 95±9 | 95±6 | 0.64 | 91±7 | 96±9 | 95±11 | 0.03 |
| Change | -7.5±9.7 | -5.7±7.6 | -5.9±6.4 | 0.51 | -6.1±10 | -8.1±8.5 | -2±19 | 0.10 | |
| 2-hour glucose (mg/dL) | Baseline | 98±32 | 100±32 | 94±25 | 0.82 | 95±31 | 104±31 | 115±25 | 0.03 |
| Change | -15±27 | -9±30 | 2.1±24 | 0.09 | -6±23 | -3.3±28 | -6.1±22 | 0.84 | |
| Fasting insulin (μU/mL) | Baseline | 14±5 | 17±18 | 16±9 | 0.42 | 10±2.4 | 15±16 | 12±3 | 0.07 |
| Change | -2.2±4 | -4.5±17 | 1.4±6 | 0.14 | 1.1±10 | -3.5±16 | -1.9±4 | 0.17 | |
| 2-hour insulin (μU/mL) | Baseline | 74±56 | 100±105 | 88±78 | 0.18 | 58±40 | 84±74 | 95±85 | 0.04 |
| Change | -17±48 | -27±71 | -7±44 | 0.40 | -12±26 | -13±56 | -23+45 | 0.58 | |
| Framingham risk score | Baseline | 7±6 | 9±7 | 7±6 | 0.51 | 2±2 | 2±2 | 1±1 | 0.12 |
| Change | -1.8±5 | -2.4±4.2 | -1.2±4 | 0.62 | -0.4±1 | -0.6±2 | -0.1±1 | 0.49 | |
Abbreviations: CRP, C-reactive protein BP, blood pressure; LDL-C, low-density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; Framingham risk score [20]