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. Author manuscript; available in PMC: 2013 Nov 19.
Published in final edited form as: Chem Res Toxicol. 2012 Aug 22;25(11):2310–2321. doi: 10.1021/tx300198h

Figure 1.

Figure 1

Covalent modification on Cys234 and Cys179 of E1 activating enzyme. MS/MS spectra obtained using a ThermoFisher LTQ-orbitrap of the S-(ethylaminocarbonyl) adduct on (A) Cys234 of E1 protein isolated from DEDC treated rats (+71 Da on the y6-y12 and b8-b12 fragments of DNPGVVTCLDEAR) and (B) Cys179 of E1 protein isolated from DEDC treated rats (+71 Da on the y7-y4 and b5-b7 fragments of VGEFCHSR).