Table 4.
Projected Mortality by Arm in PCPT and REDUCE
| PCPT | Finasteride Arm | Placebo Arm | |
|---|---|---|---|
| Death Rate per 1,000 (%of deaths)1 | Death Rate per 1,000 (%of deaths)1 | RR (95 % CI) | |
| Original Biopsy Gleason | |||
| 2-6 | 2.7 (18) | 4.3 (30) | |
| 7 | 5.4 (37) | 5.2 (37) | |
| 8-10 | 5.9 (40) | 3.8 (27) | |
| Unknown | 0.6 (4) | 1.0(7) | |
| Total | 14.6 | 14.2 | 1.02 ( 0.85-1.23) |
| Adjusted (RP Gleason) | |||
| 2-6 | 2.5 (16) | 4.0 (23) | |
| 7 | 8.6(56) | 10.6 (60) | |
| 8-10 | 4.2 (27) | 3.0 (17) | |
| Total | 15.3 | 17.6 | 0.87 (0.72-1.06) |
| Adjusted (Prostate Volume) | |||
| 2-6 | 2.7 (18) | 4.7 (29) | |
| 7 | 5.4 (37) | 6.5 (40) | |
| 8-10 | 5.9 (40) | 4.0 (25) | |
| Unknown | 0.6 (4) | 1.0(6) | |
| Total | 14.6 | 16.1 | 0.91 (0.76-1.09) |
| REDUCE | Dutasteride Arm | Placebo Arm | |
| Biopsy Gleason | Death Rate per 1,000 (% of deaths)1 | Death Rate per 1,000 (% of deaths)1 | RR (95 % CI) |
| 2-6 | 5.0 (30) | 6.9 (39) | |
| 7 | 8.2 (50) | 8.9(50) | |
| 8-10 | 3.2 (20) | 2.0(11) | |
| Total | 16.4 | 17.7 | 0.93 (0.80-1.08) |
1
Death rates based on denominator of all biopsied men